Přednáška z Anatomie a fyziologie rostlin
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19.2.2013, 15:45 |
| přednáší |
prof. Ing. Edward Trifonov, Ph.D. (University of Haifa, Israel) |
| název |
Nucleosome positioning sequence code. 33 years of agony, and final picture.
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| anotace |
The 10-11 base periodicity in eukaryotic sequences related to nucleosome positioning was discovered 33 years ago, when also the first version of the nucleosome positioning pattern: x AAAxxTTTx (xRRRxxYYYx) was suggested. It remained both poorly understood and challenged by alternative sequence motifs, with no clear consensus in chromatin community. The matter is clarified in last few years, with modern advances in sequencing and signal extraction. The final patterns all conform to the standard YRRRRRYYYYYR, with species- and isochore-specific variations.
Edward Trifonov, Professor Emeritus in The Weizmann Institute of Science and University of Haifa, Israel, is regarded as founder of Israeli bioinformatics. In his research, he specializes in the recognition of weak signal patterns in biological sequences and is known for his unorthodox scientific methods.
He discovered the rules determining the curvature of DNA molecules and their bending within nucleosomes. Trifonov unveiled multiple novel codes in biological sequences as well as the modular structure of proteins. He proposed an abiogenic theory of the origin of life, and molecular evolution from single nucleotides and amino acids to present-day DNA and protein sequences.
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| materiály |
životopis přednášejícího (PDF)
pozvánka (PDF)
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